منابع مشابه
Antiarrhythmic Actions of Diltiazem During Experimental Atrioventricular Reentrant Tachycardias
The purpose of this study was to determine if the known frequency-dependent effects of diltiazem on inward calcium current result in selective actions during supraventricular tachycardia. These effects were evaluated by use of an experimental model of orthodromic atrioventricular reentrant tachycardia (AVRT). AVRT was induced in 15 dogs over a wide range of retrograde conduction times before an...
متن کاملAntiarrhythmic and electrophysiologic actions of clofilium in experimental canine models.
Clofilium was studied in three experimental models. In non-ischemic and chronically infarcted canine hearts, clofilium (0.5-2 mg/kg) produced a dose-dependent increase in electrical ventricular fibrillation threshold (VFT), but prolonged the effective refractory period (ERP) of normal myocardium in only the non-ischemic heart. When chronically infarcted hearts were subjected to programmed elect...
متن کاملAntiarrhythmic Actions of Diltiazem During Experimental Atrioventricular Reentrant Tachycardias
The purpose of this study was to determine if the known frequency-dependent effects of diltiazem on inward calcium current result in selective actions during supraventricular tachycardia. These effects were evaluated by use of an experimental model of orthodromic atrioventricular reentrant tachycardia (AVRT). AVRT was induced in 15 dogs over a wide range of retrograde conduction times before an...
متن کاملAntiarrhythmic versus antifibrillatory actions: inference from experimental studies.
Pathophysiology of the coronary circulation is a major contributor to altering the myocardial substrate, rendering the heart susceptible to the onset of arrhythmias associated with sudden cardiac death. Antiarrhythmic drug therapy for the prevention of sudden cardiac death has been provided primarily on the basis of trial and error and in some instances based on ill-suited preclinical evaluatio...
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The adrenomimetic drugs mimic the effects of adrenergic sympathetic nerve stimulation on sympathetic effectors; these drugs are also referred to as sympathomimetic agents. The adrenergic transmitter norepinephrine and the adrenal medullary hormone epinephrine also are included under this broad heading. The adrenomimetic drugs are an important group of therapeutic agents that can be used to main...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1969
ISSN: 0021-5198
DOI: 10.1254/jjp.19.19